The cathepsin L-like proteinases of liver fluke and blood fluke parasites of the trematode genera Fasciola and Schistosoma.
نویسندگان
چکیده
J. R, Kerbel, R S., Khoo, N. and Lala, P. K. (I 993) Exp. Cell Res. 206,204-2 I I 4 I Morgan, M., Kniss, D. and McDonnell, S. (I 998) Exp. Cell Res. 242, 18-26 42 Kniss. D. A., Shubert P. J., Zimmerman, P. D., Landon, M. B. and Gabbe, S. G. ( 1994) J. Reprod. Med. 39,249-256 43 Matrisian, L M. ( I 993) Ann. N.Y. Acad. Sci. 732,42-50 44 Librach, C. L, Feigenbaum, S. L, Bass, K E., Cui, T. Y., Verastas, N., Sadovsky, Y., Quigley, J. P., French, D. L and Fisher, S. J. ( 1994) J. Biol. Chem. 269, 1-7 45 Bass, K E., Monish, D., Roth, I., Bhardwaj, D., Taylor, R, Zhou, Y. and Fisher, S. J. ( 1994) Dev. Biol. 164, 55CL56 I 46 Sedlacek R, Mauch, S., Kolb, B., Schatzlein, C., Eibel, H., Peter, H. H., Schmitt, J. and Krawinkel, U. ( I 998) lmmunobiology 198,408423 47 Pandas, A. M., Knauper, V., Puente, X. S., Llano, E., Mattei, M. G., Apte, S., Murphy, G. and Lopez-Otin, C. ( I 997) J. Biol. Chem. 272, 428 I4286 48 Whitelock J. M., Murdoch. A. D.. lozzo, R V. and Underwood, P. A. ( 1996) J. Biol. Chem. 27 I, I 0079I0086 49 Gearing, A. J., Beckett, P., Christodoulou, M.. Churchill, M., Clements, J., Davidson, A. H., Drummond, A. H., Galloway, W. A., Gilbert, R, Gordon, J. L. et al. ( I 994) Nature (London) 370,555-557
منابع مشابه
Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin.
Two cathepsin L proteinases, cathepsin L1 and cathepsin L2, secreted by liver flukes may be involved in tissue penetration, nutrition, and protection from immune attack. To ascertain the immunoprophylactic potential of these proteinases, and of another molecule, liver fluke hemoglobin (Hb), we performed vaccine trials in cattle. In the first vaccine trial various doses of cathepsin L1 were test...
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عنوان ژورنال:
- Biochemical Society transactions
دوره 27 4 شماره
صفحات -
تاریخ انتشار 1999